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They are not a sedative or a benzodiazepine, so they do not usually cause strong drowsiness or dependence

Most individuals tolerate these medications, but others may have mild to moderate side effects, particularly during the first few weeks

Over 26 weeks, tesamorelin reduced visceral adipose tissue by a mean of 34 square centimeters compared to an increase of 8 square centimeters in the placebo group

For example, NAD+-dependent enzymes include the sirtuins (SIRT1-7), a family of protein deacetylases involved in gene expression, stress responses, and metabolic regulation, as well as poly(ADP-ribose) polymerases (PARPs) that assist in DNA repair

doi: 10.1146/annurev.pharmtox.47.120505.105256

The Lancet does its own internal expert review and recruits outside experts for peer review