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The anti-diabetic efficacy of diverse polyphenols has been demonstrated in both in vivo and in vitro studies, supporting their potential as therapeutic agents (388, 389)

Third, because many biosynthetic enzymes are known to be promiscuous in the substrates that they accept, we tested whether the generated molecules could be rationalized as enzymatic transformations of known metabolites

Treg function by suppressing the activation of effector T cells, including Th17 cells, and preventing excessive inflammatory responses

As a consequence, they often become nutritionally deficient