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Several receptors facilitate RMT across the BBB, including the TfR, insulin receptor (IR), insulin-like growth factor-1 receptor (IGF1R), low-density lipoprotein receptor-related proteins (LRP1 and LRP2), neonatal Fc receptor (FcRn), and angiotensin-converting enzyme receptor (ACE)

Mller S, Kufner A, DellOrco A, Rackoll T, Mekle R, Piper SK, Fiebach JB, Villringer K, Flel A, Endres M, Ebinger M, Nave AH

When glutathione levels are depleted, these immune responses become less efficient

The profound muscle contraction generates excessive heat, leading to the extreme temperatures seen in this patient

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