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Together with the electron-impact fragmentation pattern of each identified MCF derivatised 13 C-labelled metabolite, the degree of labelling was estimated based on the variation observed in the fragmentation pattern of 13 C-labelled metabolites in comparison to their counterpart 12 C mass spectrum

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Additionally, the metabolic plasticity of cancer cells, where cells can upregulate alternative pathways or acquire nutrients from the environment to adapt to metabolic changes, poses a challenging task that will require simultaneous targeting of metabolic pathways and nutrient clearance routes

Sahebkar et al., 2015

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Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Small Cell Lung Cancer V.1.2026