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This review integrates current evidence on how brain peptides contribute to AD pathophysiology, summarizes recent progress in peptide-based therapeutic strategies and delivery platforms, and critically examines the remaining barriers to clinical translation, including bloodbrain barrier penetration, metabolic stability, off-target effects, and the need for biomarker-guided patient stratification

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Evidence from preclinical and clinical studies highlights their potential in reducing psoriasis area and severity index (PASI) scores, mitigating immune hyperactivity, and enhancing the safety and efficacy of standard therapies