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According to a study on LPS-induced ARDS, Nrf2 inhibits oxidative stress and attenuates ferroptosis via controlling the amounts of ferroptosis-related proteins, such as SLC7A11 and GPX4

ACS Omega 7(48):4440744419

In: R Nickel AS, E Seiferle, editor

These observations were performed by three independent physiatrists who were blinded to the treatment groups, ensuring unbiased assessment

This indicates that GPX4 ameliorates ferroptosis-induced neurodegeneration and cognitive impairment, alleviating synaptic loss and neuronal dysfunction in AD