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Vitamin B12 plays a vital role in various physiological processes, including energy production, metabolism, blood cell formation, and nerve function

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It can bind directly to the heme iron of NOS to trigger various chemical and biochemical reactions (e.g., NO deoxygenation associated with scavenging of NO and vasoconstriction, as ob- served for hemolytic diseases [52], or S-nitrosylation of HbA hemoglobin responsible mainly for lung injury associated with an increased formation of red blood cells [53])

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