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GCLC is sensitive to GSH-induced feedback inhibition

The study cohort included 75 patients who received metformin for the previous 6 mo or more and 75 patients who did not receive metformin for the previous 6 mo but had received other oral antihyperglycemic drugs

The BTBR mouse strain, developed as a preclinical model for ASD, displays decreased mitochondrial oxygen consumption and behavioral abnormalities that parallel core ASD symptoms

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Another randomized controlled trial showed that soybean isoflavone therapy (80 mg/day, P.O for 24 weeks) significantly increased the protein and mRNA levels of Nrf2 and the concentrations of SOD as well as diminished serum levels of inflammatory factors and MAD in patients with myocardial ischemia [139]