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In summary, ferroptosis can be triggered by blocking system x c - with exogenous small molecules, interfering with GPX4, disrupting lipid metabolism balance, and iron homeostasis

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This AMPK-mediated inhibition of the TGF-1/Smad signaling pathway is reversed by the AMPK inhibitor Compound C in hepatocyte models, confirming the central role of this pathway (66)

these models allow targeted genetic and pharmacologic manipulation of eosinophils, helping to dissect their mechanistic roles

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