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Gene therapy involves intra-articular injection of vectors into the diseased joint to promote the apoptosis of target cells or continuously express their products against pathogenic factors ( Figure 5 )

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Research suggests that inhibiting PARP1 can enhance the functionality of senescent cells by increasing NAD + levels and SIRT1 activity 159

At a concentration of 10 M, in the presence of mitochondria lysate and NADH, 2-chlorophenothiazine reduced DCF fluorescence

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