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These data now provide a mechanistic link between periodontitis and the regional and systemic effects of the disease in cats, and could lead to potential therapies for oxidative stress-induced tissue damage

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Mangiferin also upregulated the expression levels of mOAT1, indicating that it may promote UA excretion in hyperuricemic mice by inhibiting renal UA reabsorption and increasing UA secretion, thus reducing serum UA levels (54)