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Intraneuronal A load was confirmed with IHC using the antibody McSA1 which specifically recognizes N-terminal amino acids 1-12 of human A without cross-reacting to APP or its cleavage products 14,62

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Recent experiments using rats have shown that ALA can help reverse damage in aging cells of the brain, improve performance in memory tasks, lower oxidative damage and improve mitochondrial function, although we still dont know how well these benefits can apply to aging humans

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