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Following treatment with GHK or GHK-PEG, the number of cells per ml of media was assessed as previously described and the rate of cell proliferation was expressed as fold control and compared between treated and non-treated cells using analysis of variance (ANOVA)

The NIR two-photon excitation owns significant advantages over direct UVVis one-photon excitation of AuNPs because of greater tissue penetration, low autofluorescence levels and low photo damage of healthy tissues 46

Bacteriostatic water is sterile water designed for laboratory and scientific research applications

111,112,113,114 The field of osteochondral tissue engineering has matured substantially and progress towards clinically applicable replacements will be vital for the large portion of the population currently excluded from clinical trials

The molecular mechanisms underlying neuronal death include chronic inflammatory response and OS (Gaki and Papavassiliou, 2014, Stojkovska et al., 2015), which is characterised by the presence of microglial cell activation, reactive astrogliosis (Marino et al., 2020)

The capsule, especially if its an enteric-coated or delayed-release formulation, is crucial for protecting the delicate peptide from the highly acidic environment of the stomach