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In CBS-deficient mice, plasma homocysteine levels are increased and steatosis, oxidative stress, and fibrosis develop in the liver [74,75,79]

Modern multiomics platforms are now uniquely positioned to achieve this transition

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Recent studies have identified several key regulators of astrocytic antioxidant functions, including the mGLUT3 receptor, cyclic AMP, ROS-induced mitochondrial DNA release and dystrophin 85,86

In changing the frequency of the patients treatment regimens and we were conscious that we were disturbing what for many had become a regular part of their lives, often over many years