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Smyth 2017

Both studies reported a rapid reduction in pruritus severity and significant improvement in nodules after treatment (142, 143)

There are two distinct mechanisms by which B12 is absorbed: 1) passive diffusion across the mucous membranes of the gastrointestinal tract (Figure 1)

Jepson et al

The combination of strong GLP-1 appetite suppression with meaningful GIP-mediated metabolic improvement creates a synergistic effect that exceeds what either receptor could produce alone, a principle similar to why peptide stacking sometimes outperforms individual compounds