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To avoid potential bias in assessing intergroup post-intervention differences, the analysis of covariance (ANCOVA) test was applied while adjusting for possible confounding factors, such as baseline values, age, changes in energy intake, physical activity, and BMI
To evaluate the safety and tolerability of the study medications, during the active treatment period, investigators closely monitored each patient for evidence of study drug intolerance, and all adverse effects reported spontaneously by the patients or noticed by the investigators were recorded
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