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Further studies have found that when intracellular iron and lipid disorders are disturbed, 15-hydroperoxy-arachidonoyl-phosphatidyl-ethyl amino alcohol (15-HpETE-PE) will accumulate, resulting in the appearance of ferroptosis [4, 34, 50], and one of the catalysts of this reaction may be the ALOX15 and scaffold protein PE-binding protein-1 (PEBP1) complex [51, 52], NO can inhibit the catalysis of this complex, thereby inhibiting ferroptosis

J Diabetes Metab Discord 12:48 Fujihara J, Yasuda T, Iida R, Takatsuka H, Fujii Y, Takeshita H (2009) Cytochrome P450 1A1, glutathione S-transferases M1 and T1 polymorphisms in Ovambos and Mongolians

Inducing tumor cells to undergo autophagy to kill the tumor cells is a potential approach for clinical treatment and numerous studies have reported that curcumin induces autophagy in cancer cells