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J Clin Endocrinol Metab 1993;77:16417

Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes
Therefore, intrinsic cardiac load and capacity do not improve in patients with heart failure with reduced ejection fraction, and patients HFpEF benefit only from the treatment of abnormal metabolism and inflammation

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The inflammatory component often improves before structural healing becomes apparent
