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Elevated levels of 5-HTOL persist in urine for 515 h (depending on the dose) after alcohol consumption, compared to baseline measurements that suggest that ethanol persists longer in urine than in blood [37]

Temporary dose holds become necessary when side effects become intolerable despite conservative management strategies

Nevertheless, these effects are often markedly attenuated following oral administration due to their poor stability and limited bioavailability under physiological conditions

A wide range of techniques are used for assessing barrier integrity and function but each one has its own limitations that should be kept in mind when interpreting their results

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