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598 FTH1 knockdown in neurons significantly inhibits cell viability and causes mitochondrial dysfunction, while overexpression of FTH1 impairs ferritinophagy, downregulates the expression of LC3 and NCOA4, and finally inhibits cell ferroptosis

After 24 h, cells were lysed and the luciferase activity was assayed in the lysates using Promegas Dual-luciferase assay system according to the manufacturers protocol (Promega, Madrid, Spain)

53 In NK cells, SIRT2 and SIRT6 contribute to exhaustion in colorectal cancer, suppressing NK cytotoxicity by downregulating glycolysis and mitochondrial respiration

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The pediatric preclinical testing program: description of models and early testing results

Since rare diseases are almost always synonymous with high unmet needs, these therapies collected a record number of coveted FDA designations, especially orphan drugs (31), priority reviews (26), fast-track (16), and breakthrough therapy (12)