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doi: 10.1089/thy.2005.15.841

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These findings indicate that VPA exposure induces a pronounced neuroinflammatory state characterized by proinflammatory cytokine upregulation and anti-inflammatory cytokine suppression, which is effectively normalized by hCiPSC-NSCs treatment

Results GSDMD-mediated pyroptosis is activated in ischemic hindlimbs To investigate the involvement of GSDMD-mediated pyroptosis in hindlimb ischemic injury in vivo, we established hindlimb ischemia (HLI) model by ligation of the femoral artery in wild-type (WT) mice