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Zileuton, a 5-LOX inhibitor approved by the FDA and formerly employed in the treatment of asthma, is presently under evaluation for clinical trials in the management of PF [189]

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Safety profiles vary significantly : IV administration carries serious risks including anaphylaxis, hepatotoxicity, and potential endotoxin contamination, while oral supplements typically cause only mild gastrointestinal effects like flatulence or loose stools

Naturwissenschaften 66:377382 Kwak JM, Mori IC, Pei ZM, Leonhardt N, Torres MA, Dangl JL, Bloom RE, Bodde S, Jones JD, Schroeder JI (2003) NADPH oxidase AtrbohD and AtrbohF genes function in ROS-dependent ABA signaling in Arabidopsis

Ultimately, the occurrence of epileptic seizures may be the cause and consequence of reactive oxygen radicals

When the entire colon is absent or not in continuity, patients lose the endogenous vitamins and nutrients typically produced by the gut microbiota, including vitamins K and B, folic acid, and short-chain fatty acids