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Int J Oncol 53:23192331

Sometimes it's even used as part of microneedling, which can be effective but can also be painful or uncomfortable

The deposition of misfolded proteins within the ER lumen sets off a series of cascades aimed at restoring intracellular homeostasis (Fig

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doi: 10.1096/fj.05-3735fje

Examples of these specific detoxification systems are the glyoxalase system, which removes the reactive aldehyde methylglyoxal, [4] and the various antioxidant systems that eliminate reactive oxygen species
