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"Systemic Pharmacologic Therapies for Low Back Pain: A Systematic Review for an American College of Physicians Clinical Practice Guideline." Annals of Internal Medicine , 173(10):805-821

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This is a naturally-occurring form of IGF-1, meaning it is not made in a lab

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doi:10.7759/cureus.1734

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Initial interventions for well localized or sympathetically maintained pain include epidural steroid injections or selective nerve root blocks for radicular pain (e.g., sciatica), and sympathetic nerve blocks (e.g., stellate ganglion, lumbar sympathetic) for conditions like complex regional pain syndrome, which can provide both diagnostic information and therapeutic relief [41]

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