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Disturbances of intestinal wall permeability can potentially lead to unwanted activation of the enteric immune system due to excessive contact with gut microbiota and its components, and the development of endotoxemia, when the level of bacterial lipopolysaccharides increases in the blood, causing chronic low-intensity inflammation

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In addition to glucose, an increased influx of glutamine into cells has been linked to the development of resistance to chemotherapy and endocrine therapies by activating pathways that support both survival and proliferation [16]

Mitochondria are also involved in the induction of autophagy 61,62