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Elife 9:e62116

1 and Supplementary Figs

While the efficacy data did not survive the Phase IIb primary endpoint, the safety dataset across 900 participants is unusual for a research peptide and is consistently cited as the basis for continued investigational interest

Muscle contractile function was markedly restored, accompanied by significantly elevated proliferation activity and number of muscle stem cells, as well as upregulated expression of myogenic differentiationrelated genes

An additional peak of protection was seen at 10 13 M (100 fM) but was inconsistent across experiments, so all additional experiments were run with 10 6 M (1 M) Dihexa

Most studies report: No observable toxicity No organ damage No carcinogenic findings in short-term studies However: Long-term human clinical data is limited Most evidence remains preclinical Reference: Sikiric et al., 2018 safety review Summary: BPC-157 Peptide BPC 157 peptides are among the most studied regenerative peptides in experimental research