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Curcumin analog ALZ003 can induce ubiquitination degradation of androgen receptor and significantly increase the sensitivity of GBM cells to temozolomide both in vitro and in vivo, and the mechanism may be related to ROS accumulation, lipid peroxidation and inhibition of GPX4, which are major features of ferroptosis

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[DOI] [PubMed] [Google Scholar] Darley-Usmar VM, Severn A, et al

Med 52 , 11231134 (2012)

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