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Back to Journals Vascular Health and Risk Management Volume 12 SGLT2 inhibitors or GLP-1 receptor agonists as second-line therapy in type 2 diabetes: patient selection and perspectives Authors Gurgle H, White K, McAdam-Marx C Received 14 November 2015 Accepted for publication 11 March 2016 Published 4 June 2016 Volume 2016:12 Pages 239249 DOI Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 5 Editor who approved publication: Dr Daniel Duprez Holly E Gurgle, Karen White, Carrie McAdam-Marx Department of Pharmacotherapy, University of Utah College of Pharmacy, Salt Lake City, UT, USA Abstract: Controversy exists regarding the selection of second-line therapy for patients with type 2 diabetes mellitus (T2DM) who are unable to achieve glycemic control with metformin therapy alone

We posit that the surge in fetal blood IGF-1 is a compensatory response to the maternal GLP-1RA-induced fetal growth restriction

46 Finally, Klonoff et al, using the Arcadia patient registry, also found no significant increase in NAION risk in patients taking semaglutide

Many people start at a low dose and titrate upward to a maintenance level, which can affect side effect patterns

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