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Compared with steroidal MRAs, non-steroidal MRAs exert stronger anti-inflammatory and anti-fibrotic effects, probably related to their distinct effects on tissue-specific gene activation [67]

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With antiamyloid antibodies Leqembi (lecanemab) and Kisunla (donanemab) now FDAapproved for early Alzheimers, attention is turning to combination strategies that address multiple disease pathways