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Despite the fact that meldonium is thought to be relatively safe and the number of side effects was found to be lower than 15% in clinical studies, 5 some potential complications have been reported, including 1 case of sudden death after peripheral embolism and ischaemic stroke (reported by a physician from the Russian Federation in a 69-year-old patient using multiple drugs other than meldonium), 1 case of multi-organ failure (reported by a health professional from Ukraine in a 74-year-old patient), along with additional cases of patients with diarrhoea, anaemia, fatigue, and serum bilirubin increase

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This balances glycogen levels by reducing carbohydrate use, the same as using more body fat

Therefore, F6P presence acts as an inhibitor of GCK activity, but the generation of F1P promotes its activation

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