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This setup lets you strip away all the other biological noise and focus only on how the pituitary cells respond

Furthermore, EGCG suppresses key signaling pathways such as the PI3K/AKT/mTOR and AMPK pathways, and also inhibits factors like ROS, iNOS, Cox-2, NF- B, Senescence-associated secretory phenotype (SASP), and p53-mediated cell cycle regulation in preadipocytes [558]

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In such scenarios, neurons are prone to spontaneous apoptosis due to insufficient ATP production, whereas astrocytes demonstrate greater resilience