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Description
It was also discovered that the PGC-1/NRF2 pathway, responsible for oxidative stress regulation and cellular metabolism, was suppressed, resulting in amplified levels of ROS in the PC cells

Severely damaged RBCs isolated from early crises had extensive membrane cross-bonding and very low GSH levels and were phagocytosed 10-fold more intensely compared to normal RBCs
NMDAN-methyl-D-aspartate receptor

SARS-CoV-2 has been shown to decrease GSH by reducing Cys uptake, increasing thiol efflux, inhibiting Nrf2, and inhibiting BRCA1
H., Al-Farhan B

To obtain further insights into the molecular mechanism underlying SnCE1 autoproteolytic processing, we constructed a mutant of SnCE1, i.e., SnCE1 C256A S/T/C_to_A