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The microbiome in mental health: potential contribution of gut microbiota in disease and pharmacotherapy management

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It applies an ascending course that gradually affects the midbrain, especially the substantia nigra, and spreads from there to impair the mesocortex and neocortex

A study conducted over 12 months in obese adults concluded that a daily dose of 6 g of CLA is safe and well-tolerated, with changes in glucose metabolism that were transient, and liver and insulin markers remained stable, contrasting with some previous animal studies that reported concerns about insulin resistance and liver toxicity [221,222,223]
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10.1186/s12906-018-2127-7 180 XieQ.ChenY.TanH.LiuB.ZhengL

Ruggeri M, Vigani B, Boselli C, Icaro Cornaglia A, Colombo D, Snchez-Espejo R, et al