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Blood 2008;112, 1005-1012, doi:10.1182/blood-2008-02-140665

The stability of transition-metal complexes

Suppression of Wnt/-catenin signaling decreases -catenin levels and downstream oncogene expression, promoting apoptosis and limiting cancer progression

Kato T, Natsume A, Toda H, Iwamizu H, Sugita T, Hachisu R, Watanabe R, Yuki K, Motomura K, Bankiewicz K, Wakabayashi T (2010) Efficient delivery of liposome-mediated MGMT-siRNA reinforces the cytotoxity of temozolomide in GBM-initiating cells

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Inhibiting the activity of system Xc- prevents the absorption of cystine, affects GSH synthesis, and subsequently reduces GPX4 activity (the membrane lipid-repair enzyme), thus reducing the cellular antioxidant capacity and promoting ferroptosis (Figure 1B) (Chen et al., 2021a