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[DOI] [PubMed] [Google Scholar] 6.Jensen MD, Ryan DH, Apovian CM, Ard JD, Comuzzie AG, Donato KA, Hu FB, Hubbard VS, Jakicic JM, Kushner RF, Loria CM, Millen BE, Nonas CA, Pi-Sunyer FX, Stevens J, Stevens VJ, Wadden TA, Wolfe BM, Yanovski SZ G

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The first type occurs as a result of injuries while the second develops over time with the natural wearing out of the cartilage with age or as a side effect of inflammatory diseases such as rheumatoid arthritis or gout

IL1 plays a major role in gouty inflammation

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