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Liposomal membrane lipid composition is an important criterion to control the desired drug release pattern 10,11

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146 TGF- induces ubiquitination degradation of MyD88 to negatively regulate pro-inflammatory signaling, specifically through the recruitment of Smad ubiquitination regulatory factor (Smurf) 1 and Smurf2 with E3 ubiquitin ligase activity by Smad6

Furthermore, the inclusion of the Klotho protein can enhance the formation of the ULK1 complex transcription factor EB nuclear translocation and block the IGF1/PI3K/Akt/mTOR signaling pathway, all of which are essential for autophagy activation [150]

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