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This mechanistically supports the use of such vitamin antioxidant combinations for DR [44, 50]

Sirtuins, particularly SIRT1, need NAD+ as a cofactor for protein deacetylation

Thrombin is a naturally occurring protein essential for wound healing
The imbalance of Th17 and Tregs can lead to an abnormal immune response (Zhao et al., 2017

doi:10.3390/ijms19020341

IgG abzymes with peroxidase and oxidoreductase activities from the sera of healthy humans
