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It is not clear if the injection affects driving ability

In line with this hypothesis, a knock-in mice, expressing a MOR chimera where the C-terminus tail was replaced by the C-terminus tail of DOR, demonstrated less tolerance after chronic morphine treatment (Kim et al., 2008), correlated to a decrease of tolerance biomarkers (He et al., 2009)

In addition, impaired glymphatic or paravascular clearance in AD may alter the elimination of brain-delivered nanoparticles, potentially affecting retention, regional distribution, and long-term safety during repeated dosing (Gu et al., 2020

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