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The main pharmacological effects and underlying mechanism of action of rutin contribute to its antioxidant capacity through the Nrf2/ARE and anti-inflammatory properties due to NF-B, COX-2, IL-6, and TNF- suppression
Furthermore, 7-day BMSC cultures from unloaded rats exhibit resistance to the anabolic effects of IGF-1 as shown by failure of IGF-1 to stimulate phosphorylation of its receptor despite unchanged IGF-1R levels and normal binding of IGF-1 to its receptor (Sakata et al., 2004)
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