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Stage 4: Chronic Tinnitus (Neuroplastic Phase) Maladaptive cortical changes and thalamocortical dysrhythmias intensify tinnitus

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The main changes in AGE during aging process are indicated as follows [4]: Table 1

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Megalencephalic leukoencephalopathy with subcortical cysts (MLC), is another primary leukodystrophy caused by recessive pathogenesis variants in the genes MLC1 (Modulator of VRAC Current 1) or HEPACAM (Hepatic and Glial Cell Adhesion Molecule, previously known as GlialCAM ) 338

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