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Ongoing trials (eg, TAME trial for Metformin, D+Q trials for aging-related diseases) will provide critical insights, but more diverse human studies are required.127 Bioavailability Challenge: In terms of translational application, bioavailability remains a significant challenge for many senolytic compounds, particularly plant-derived polyphenols such as fisetin and quercetin, which exhibit poor oral absorption, rapid metabolism, and low systemic retention
10.1093/jxb/erv306 J
Though information is scarce, a review of the literature did show some improvements in sperm density, motility, and morphology in 2 small studies
helveticus is proven to be effective in reducing the inflammation and body weight in the mice model (Bai et al., 2020)
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