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monnieri in rats with oxidative stress-induced parameters has shown that co-administration of these drugs causes additional effects in rats compared to the treatment with single substances [144, 145]

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DOI:10.1007/s00204-023-03562-9 12

At least, nine members of TRP superfamily are activated by oxidative stress including TRPM2, TRPM7, TRPA1, TRPC3, TRPC5, TRPC6, TRPV1, TRPV3, and TRPV4 (Ogawa et al., 2016)

Notably, many candidates belonged to the transient receptor potential (TRP) family of channels, well-recognized for their roles in mechanosensing 41 (Fig

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