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Although there has been great progress in HD pathogenesis, currently available neuroprotective treatment strategies are still insufficient

These microbial alterations are thought to contribute to IBS symptoms like bloating, abdominal pain, and altered bowel movements by affecting gut permeability, immune response, and gut-brain signaling ( Ruminococcus, Clostridium, and Dorea, while the amount of Bifidobacterium and Faecalibacterium spp

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Though detailed mechanisms underlying such gender disparities remain incompletely understood, gonadal hormones (particularly estrogen and testosterone) have been found with profound roles [113, 124]