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pGlu can be formed when glutamine or glutamic acid spontaneously convert into pyroglutamate

In addition to extracellular catabolism, intracellular GSH degradation is mediated by the ChaC GSH specific gamma-glutamylcyclotransferase family (CHAC1 and CHAC2), which cleaves GSH into 5-oxoproline and Cys-Gly 28,29

Red depicts factors with significant differences in group medians and significant correlations with LCPS

Absorption of the majority of the nutrients takes places in the jejunum, with a few exceptions: iron is absorbed in the duodenum, and vitamin B12 and bile salts are absorbed in the terminal ileum

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This process is believed to start with a depletion of GSH within the mitochondria, the "power plants" of cells