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Ethics declarations Ethics approval and consent to participate All experimental procedures, including the treatment of animals, were reviewed and approved by the Ethical Committee on Health of the National Research and Innovation Agency, Republic of Indonesia (053/KE.03/SK/05/2023)

This is a common concern regardless of what other medications are in the picture

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doi: 10.7150/THNO.33452 132 KarapetsaM.PitsikaM.GoutzourelasN.StagosD.Tousia BeckerA.ZakynthinosE

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These depleted antiviral T cells (PD-1+/Tim-3+) are functionally ineffective, as they are unable to activate and exert their cytotoxic functions in response to antigenic stimulation [227, 229], thus allowing the infection to become even more chronic