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However, when activated in response to injury, infection, or disease, microglia can change into a pro-inflammatory state, producing a wide range of inflammatory molecules such as cytokines (e.g., TNF-, IL-1), ROS, and proteases, all of which contribute to tissue damage and neurodegeneration [140]

Statements Author contributions TD: Writingreview and editing, Writingoriginal draft, Visualization, Investigation, Data curation, Conceptualization

Modern frost-free refrigerators may have larger swings than older manual-defrost models

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Modulation of the hypothalamic-pituitary-adrenal axis by early life stress exposure