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Endocrinology (2018) 159:5708
Structure and catalytic mechanism of human steroid 5beta-reductase (AKR1D1)
"Two concentrations of topical tretinoin (retinoic acid) cause similar improvement of photoaging but different degrees of irritation: a double-blind, vehicle-controlled comparison of 0.1% and 0.025% tretinoin creams." Archives of dermatology 131.9 (1995): 1037-1044
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When levels are low, the immune system is more likely to stay stuck in an overactive state
