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Identification of a mononucleotide repeat as a major target for mitochondrial DNA alterations in human tumors

The increase of free iron leads to Fenton reaction (Fe 2+ + H 2 O 2 Fe 3+ + OH + OH ), resulting in ROS accumulation and non-enzymatic lipid peroxidation, which leads to the imbalance of antioxidant system and membrane integrity defect, and finally leads to ferroptosis (Forcina and Dixon 2019) (Fig

As GST isozymes (in particular GST ) are frequently upregulated in many solid tumors and lymphomas, prodrugs activated by GST-mediated catalysis have become a viable drug design concept

The supply of amino acids might come from protein recycling or being compensated by downregulation of the synthesis of other polymers such as flagellum assembly, but this supply seems to be insufficient, according to our results

Its metabolism primarily depends on the liver

Novel in vitro and mathematical models for the prediction of chemical toxicity
