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It is a major source for methyl groups via its metabolite trimethylglycine (betaine) that participates in the S-adenosylmethionine synthesis pathways

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Garcia-Prez ME, Stevanovic T, Poubelle PE
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Nicotinamide vs Niacin: Whats the Difference

Introducing a second agent with a different mechanism can restart progress by circumventing the specific adaptations the body made in response to the first compound
