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Contact your GP if: You have been found to have elevated B12 levels and have not received an explanation or follow-up plan You are taking high-dose B12 supplements without medical supervision You develop new symptoms whilst taking B12 supplements, particularly skin changes, persistent headaches, or gastrointestinal symptoms You have risk factors for liver disease (alcohol excess, viral hepatitis, obesity) and have elevated B12 You experience unexplained weight loss, night sweats, or persistent fatigue alongside elevated B12 Seek urgent medical attention if you experience: Jaundice (yellowing of skin or eyes) Severe abdominal pain or swelling Unexplained bruising or bleeding Confusion or altered consciousness Severe, persistent vomiting These symptoms may indicate serious underlying conditions such as acute liver failure, haematological emergencies, or other critical illness requiring immediate assessment

Staff NP, Windebank AJ

These side effects may include: Pain, redness, or swelling at the injection site Headache Fatigue Dizziness Blurred vision Serious side effects from vitamin B12 injections are rare

Pramlintide (approved 2005): three-amino-acid substitution enabling solubility, 2-3 daily dosing before meals, approximately 23% weight loss in T2D

This helps maintain the treatment regimen that is essential for their health

Yang, S